Expresión de búsqueda:
FIBRILLIN-1
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DeCS
Descriptor
Inglés
:
Fibrillin-1
Descriptor
Español
:
fibrilina-1
Descriptor
Portugués
:
Fibrilina-1
Sinónimos
Inglés
:
Fibrillin 1
Profibrillin 1
Profibrillin-1
Categoría:
D09.400.430.875.500
D12.776.395.341.500
D12.776.860.300.400.500
Definición
Inglés
:
A
fibrillin
(FBN1) that functions as a structural support protein for
MICROFIBRILS
. It also regulates the maturation of
OSTEOBLASTS
by controlling the availability and concentration of TGF-BETA and
BONE MORPHOGENETIC PROTEINS
.
Mutations
in the FBN1 gene are associated with
MARFAN SYNDROME.
Nota Histórica
Inglés
:
2017; use FIBRILLIN 1985-2016
Calificadores Permitidos
Inglés
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número del Registro:
56520
Identificador Único:
D000071838
Ocurrencia en la BVS
:
Similar:
DeCS