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MFN=56996
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DeCS
Descriptor
Inglés
:
Valosin Containing Protein
Descriptor
Español
:
proteína que contiene valosina
Descriptor
Portugués
:
Proteína com Valosina
Sinónimos
Inglés
:
CDC48 Protein
Cell Cycle Protein CDC48
Cell Cycle Protein CDC48p
Valosin-Containing Protein
Valosin-Containing Protein, p97
Valosine Containing Protein
Valosine-Containing Protein
p97 Valosin Containing Protein
p97 Valosin-Containing Protein
Categoría:
D08.811.277.040.013.500.750
D08.811.277.040.025.024.750
D12.776.157.025.750.750
D12.776.167.800
Definición
Inglés
:
A highly-conserved AAA ATPase that functions in the biogenesis of the transitional
ENDOPLASMIC RETICULUM
and fragmentation and reassembly of the
GOLGI APPARATUS
during
MITOSIS
. It also functions in a complex with UFD1L and NPLOC4
proteins
to export misfolded
ubiquitinated proteins
from the
endoplasmic reticulum
and outer mitochondrial membrane to the
cytoplasm
for degradation by the PROTEASOME and also plays a role in
AUTOPHAGY
of
ubiquitinated proteins
. It occurs in neuronal
INCLUSION BODIES
from
patients
with
AMYOTROPHIC LATERAL SCLEROSIS
and
LEWY BODIES
from
PARKINSON DISEASE
patients.
Nota Histórica
Inglés
:
2018 (1991)
Calificadores Permitidos
Inglés
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número del Registro:
56996
Identificador Único:
D000074405
Ocurrencia en la BVS
:
Similar:
DeCS