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MFN=57033
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DeCS
Descriptor
Inglés
:
WNK Lysine-Deficient Protein Kinase 1
Descriptor
Español
:
proteína quinasa deficiente en lisina WNK1
Descriptor
Portugués
:
Proteína Quinase 1 Deficiente de Lisina WNK
Sinónimos
Inglés
:
WNK Lysine Deficient Protein Kinase 1
Categoría:
D08.811.913.696.620.682.700.982
D12.644.360.975
D12.776.476.944
D23.050.301.500.600.962
D23.050.705.552.600.925
Definición
Inglés
:
A serine-threonine kinase which plays an important role in the regulation of electrolyte
homeostasis
, cell signaling,
survival
, and proliferation. It functions as an activator and inhibitor of sodium-coupled chloride co-transporters and as an inhibitor of potassium-coupled chloride co-transporters.
Mutations
in the WNK1 gene are associated with type 2C
PSEUDOHYPOALDOSTERONISM
and type 2A
HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES.
Nota Histórica
Inglés
:
2018
Calificadores Permitidos
Inglés
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número del Registro:
57033
Identificador Único:
D000076204
Ocurrencia en la BVS
:
Similar:
DeCS