Expresión de búsqueda: MFN=57035 
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Descriptor Inglés:   Discs Large Homolog 1 Protein 
Descriptor Español:   homólogo 1 de la proteína discs large 
Descriptor Portugués:   Proteína 1 Homóloga a Discs-Large 
Sinónimos Inglés:   Synapse Associated Protein 97
Synapse-Associated Protein 97  
Categoría:   D08.811.913.696.650.450.500
D12.644.360.024.287
D12.776.157.057.023
D12.776.476.024.325
D12.776.543.213
Definición Inglés:   A signaling adaptor protein that contains three PDZ DOMAINS; an SH3 DOMAIN; and a GUANYLATE KINASE-like C-terminal region. It has an essential role in animal development and recruits ion channels, receptors, and signaling molecules to discrete plasma membrane regions of polarized cells in the HEART ATRIA MYOCARDIUM. It functions in the assembly of ADHERENS JUNCTIONS and regulation of CELL PROLIFERATION; synaptogenesis, LYMPHOCYTE ACTIVATION; and controls expression of KV4 POTASSIUM CHANNELS to regulate excitability of CARDIAC MYOCYTES. 
Nota Histórica Inglés:   2018 
Calificadores Permitidos Inglés:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número del Registro:   57035 
Identificador Único:   D000074288 

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DeCS