Expresión de búsqueda: MFN=57104 
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Descriptor Inglés:   KRIT1 Protein 
Descriptor Español:   proteína KRIT1 
Descriptor Portugués:   Proteína KRIT1 
Sinónimos Inglés:   Cerebral Cavernous Malformations 1 Protein
Krev Interaction Trapped Protein 1  
Categoría:   D12.776.220.600.450.458
D12.776.624.664.700.119
D12.776.631.560.465
Definición Inglés:   A microtubule-associated protein consisting of four ANKYRIN REPEATS and a C-terminal FERM DOMAIN. It links the CYTOSKELETON to CELL JUNCTIONS via integrin cytoplasmic domain-associated protein-1 and plays an important role in regulating cell proliferation and integrity of endothelial cell junctions. It is also involved in REACTIVE OXYGEN SPECIES metabolism. Mutations in the KRIT1 gene are associated with type I CEREBRAL CAVERNOUS MALFORMATIONS. 
Nota Histórica Inglés:   2018 
Calificadores Permitidos Inglés:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número del Registro:   57104 
Identificador Único:   D000075927 

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