Search on: BECLIN-1 
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Descriptor English:   Beclin-1 
Descriptor Spanish:   beclina-1 
Descriptor Portuguese:   Proteína Beclina-1 
Synonyms English:   ATG 6 Protein
ATG-6 Protein
ATG6 Protein
Beclin 1
Beclin 1 Protein
Beclin-1 Protein
Beclin1
Coiled coil Myosin like Bcl2 interacting Protein
Coiled-coil Myosin-like Bcl2-interacting Protein
GT197 Protein  
Tree Number:   D12.644.360.075.335
D12.776.094.500
D12.776.476.075.335
Definition English:   An autophagy related protein which functions as a core subunit of PHOSPHATIDYLINOSITOL 3-KINASE MULTIPROTEIN COMPLEXES. It mediates the formation of phosphatidylinositol 3-phosphate and functions in AUTOPHAGY, where it is required for maturation of the AUTOPHAGOSOME. It also functions in ENDOCYTOSIS and CYTOKINESIS as part of a separate complex. Beclin-1 associates with INTRACELLULAR MEMBRANES and interacts with the PROTO-ONCOGENE PROTEINS C-BCL-2 and BCL-X PROTEIN. 
History Note English:   2017 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   56546 
Unique Identifier:   D000071186 

Occurrence in VHL:
 

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