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CONOTOXINS
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DeCS
Descriptor
English
:
Conotoxins
Descriptor
Spanish
:
conotoxinas
Descriptor
Portuguese
:
Conotoxinas
Synonyms
English
:
Conotoxin
alpha Conotoxin
alpha Conotoxins
alpha-Conotoxin
alpha-Conotoxins
mu Conotoxin
mu Conotoxins
mu-Conotoxin
mu-Conotoxins
Tree Number:
D20.888.590.162
D23.946.580.590.162
D23.946.833.590.162
Definition
English
:
Peptide
neurotoxins
from the marine fish-hunting
snails
of the genus CONUS. They contain 13 to 29
amino acids
which are strongly basic and are highly cross-linked by disulfide bonds. There are three types of
conotoxins
, omega-, alpha-, and mu-.
OMEGA-CONOTOXINS
inhibit voltage-activated entry of
calcium
into the presynaptic membrane and therefore the release of
ACETYLCHOLINE
. Alpha-conotoxins inhibit the postsynaptic
acetylcholine
receptor. Mu-conotoxins prevent the generation of muscle
action potentials
. (From Concise
Encyclopedia
Biochemistry
and
Molecular Biology
, 3rd ed)
Indexing Annotation
English
:
OMEGA-CONOTOXINS
and
OMEGA-CONOTOXIN GVIA
are available
Pharmacological Action:
Calcium Channel Blockers
Neurotoxins
History Note
English
:
2000
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
34514
Unique Identifier:
D020916
Occurrence in VHL
:
Similar:
DeCS