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DISINTEGRINS
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DeCS
Descriptor
English
:
Disintegrins
Descriptor
Spanish
:
desintegrinas
Descriptor
Portuguese
:
Desintegrinas
Tree Number:
D12.644.138
Definition
English
:
A
family
of
polypeptides
purified from
snake venoms
, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions.
Disintegrins
thus block adhesive functions and act as
platelet aggregation inhibitors.
Indexing Annotation
English
:
polypeptides
from snake venom;
platelet aggregation
inhib
Pharmacological Action:
Platelet Aggregation Inhibitors
History Note
English
:
97; was DISINTEGRINS (NM) 1992-96
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
33035
Unique Identifier:
D019483
Occurrence in VHL
:
Similar:
DeCS