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DYSTROPHIN
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DeCS
Descriptor
English
:
Dystrophin
Descriptor
Spanish
:
distrofina
Descriptor
Portuguese
:
Distrofina
Tree Number:
D12.776.210.500.250
D12.776.220.250
D12.776.543.250
Definition
English
:
A muscle protein localized in surface
membranes
which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack
dystrophin
completely while those with Becker muscular dystrophy have
dystrophin
of an altered size. It shares features with other
cytoskeletal proteins
such as
SPECTRIN
and alpha-actinin but the precise function of
dystrophin
is not clear. One possible role might be to preserve the integrity and alignment of the
plasma
membrane to the
myofibrils
during
muscle contraction
and
relaxation
. MW 400 kDa.
Indexing Annotation
English
:
a muscle protein: see MeSH definition for relation to musc dystrophy; /biosyn /drug eff /physiol /ultrastruct permitted
See Related
English
:
Mice, Inbred mdx
Muscular Dystrophy, Duchenne
History Note
English
:
91
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
28916
Unique Identifier:
D016189
Occurrence in VHL
:
Similar:
DeCS