Search on:
PERILIPINS
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
Perilipins
Descriptor
Spanish
:
perilipinas
Descriptor
Portuguese
:
Perilipinas
Synonyms
English
:
PAT Proteins
PLIN Proteins
Perilipin Adipophilin TIP47 Proteins
Perilipin Proteins
Perilipin-Adipophilin-TIP47 Proteins
Proteins, PAT
Proteins, PLIN
Proteins, Perilipin
Proteins, Perilipin-Adipophilin-TIP47
Tree Number:
D12.776.157.464.500
Definition
English
:
A
family
of
vertebrate
and insect
lipid droplet associated proteins
. They consist of a conserved N-terminal PAT domain (an alpha-helical region of about 110
amino acids
), an 11-mer repeat region, and lipid-binding hydrophobic regions or 4-helix bundles near their C-termini.
Perilipins
transiently or constitutively localize to
LIPID DROPLETS
in
ADIPOCYTES
and
FOAM CELLS
, especially in regions adjacent to the
PLASMA
MEMBRANE and ENDOPLASMIC RECTICULUM. They are critical for lipid droplet synthesis and
homeostasis
as well as the regulation of
lipid metabolism
. Genetic variations in
perilipins
are associated with
ATHEROSCLEROSIS
;
OBESITY
; and
DIABETES MELLITUS.
History Note
English
:
2017
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
56570
Unique Identifier:
D000070137
Occurrence in VHL
:
Similar:
DeCS