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TENSINS
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DeCS
Descriptor
English
:
Tensins
Descriptor
Spanish
:
tensinas
Descriptor
Portuguese
:
Tensinas
Synonyms
English
:
Tensin
Tree Number:
D05.750.078.730.719
D12.776.220.525.719
Definition
English
:
A
family
of multidomain
microfilament proteins
that bind ACTIN FILAMENTS and
INTEGRINS
at
FOCAL ADHESIONS
. They generally consist of an N-terminal domain with homology to
PHOSPHOTYROSINE
PHOSPHATASE, a C2 DOMAIN; unique central regions rich in
PROLINE
;
ALANINE
;
GLYCINE
; and
SERINE
; an SH2 DOMAIN; and a C-terminal phosphotyrosine-binding region. They are involved in CELL MIGRATION;
CELL ADHESION
;
SIGNAL TRANSDUCTION
; and reorganization of the
CYTOSKELETON.
History Note
English
:
2017 (1992)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
56436
Unique Identifier:
D000070876
Occurrence in VHL
:
Similar:
DeCS