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Descriptor English:   Podophyllotoxin 
Descriptor Spanish:   podofilotoxina 
Descriptor Portuguese:   Podofilotoxina 
Synonyms English:   CPH86
Condyline
Condylox
Epipodophyllotoxin
Podocon-25
Podofilm
Podofilox
Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 alpha))-Isomer
Podophyllotoxin, (5R-(5 alpha,5a alpha,8a alpha,9 beta))-Isomer
Podophyllotoxin, (5R-(5 alpha,5a alpha,8a beta,9 alpha))-Isomer
Podophyllotoxin, (5R-(5 alpha,5a beta,8a alpha,9 beta))-Isomer
Wartec
Warticon  
Tree Number:   D02.455.426.559.389.140.450.777
D02.455.426.559.847.638.960.675
D04.615.638.960.675
Definition English:   A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives. 
Indexing Annotation English:   /biosyn permitted if by plant
Pharmacological Action:   Antineoplastic Agents, Phytogenic
Keratolytic Agents
Tubulin Modulators
 
History Note English:   73; EPIPODOPHYLLOTOXIN was see under PODOPHYLLOTOXIN 1975 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   11464 
Unique Identifier:   D011034 

Occurrence in VHL: 		 

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DeCS