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DeCS
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Descriptor English:
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Mechanistic Target of Rapamycin Complex 2
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Descriptor Spanish:
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diana mecanicista del complejo 2 de la rapamicina
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Descriptor Portuguese:
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Alvo Mecanístico do Complexo 2 de Rapamicina
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Synonyms English:
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Complex 2, TOR
MTORC-2
TOR Complex 2
TORC2
Target of Rapamycin Complex 2
mTORC2
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Tree Number:
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D05.500.356
D08.811.913.696.620.682.700.931.750
D12.776.476.925.750
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Definition English:
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A multiprotein complex consisting of MTOR KINASE; MLST8 PROTEIN; rapamycin-insensitive companion of mTOR protein (RICTOR PROTEIN); and PRR5 (proline-rich protein 5). Like MTORC1, it also regulates cell growth and proliferation in response to growth factors but may not be as sensitive to nutrient availability and is insensitive to SIROLIMUS. In contrast to MTORC1, it can regulate the ACTIN CYTOSKELETON through RHO GTPASES to promote the formation of STRESS FIBERS. The mTORC2 complex also plays a critical role in AKT1 PROTEIN KINASE phosphorylation and activation. |
History Note English:
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2018 (2013)
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Allowable Qualifiers English:
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Record Number:
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56985
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Unique Identifier:
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D000076225
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Occurrence in VHL:
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Similar:
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DeCS
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