|
1 / 1
|
DeCS
|
|
 |
|
Descriptor English:
|
|
Deubiquitinating Enzyme CYLD
|
|
Descriptor Spanish:
|
|
enzima desubiquitinante CYLD
|
|
Descriptor Portuguese:
|
|
Enzima Desubiquitinante CYLD
|
|
Synonyms English:
|
|
CYLD Protein
CYLD, Deubiquitinating Enzyme
Cylindromatosis Protein
Cylindromatosis, Deubiquitinating Enzyme
Deubiquitinating Enzyme Cylindromatosis
|
|
Tree Number:
|
|
D08.811.037.375
D12.776.624.776.482
|
|
Definition English:
|
|
A deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation, and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL CYLINDROMATOSIS. |
|
History Note English:
|
|
2018
|
|
Allowable Qualifiers English:
|
|
|
|
Record Number:
|
|
56989
|
|
Unique Identifier:
|
|
D000074749
|
Occurrence in VHL:
|
|
|
Similar:
|
|
DeCS
|