Search on: MFN=57004 
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Descriptor English:   MRE11 Homologue Protein 
Descriptor Spanish:   proteína homóloga de MRE11 
Descriptor Portuguese:   Proteína Homóloga a MRE11 
Synonyms English:   Homologue Protein, MRE11
MRE11A Protein
Meiotic Recombination 11 Homolog 1 Protein  
Tree Number:   D08.811.277.352.335.350.650
D08.811.277.352.335.375.813
D08.811.277.352.355.325.600
D08.811.277.352.365.290.250
D12.776.157.687.495
D12.776.260.539
D12.776.660.720.495
Definition English:   A component of the MRN complex along with Rad50 and Nibrin. Together, these perform a critical function in the repair of DOUBLE-STRANDED DNA BREAKS; RECOMBINATIONAL DNA REPAIR; maintenance of TELOMERE integrity and MEIOSIS. MRE11, which contains a poly(ADP)-ribose binding motif and associates with PARP1, possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Mutations in the MRE11 gene are associated with ATAXIA-TELANGIECTASIA-like disorder 1. 
History Note English:   2018 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   57004 
Unique Identifier:   D000076228 

Occurrence in VHL:
 

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