Search on: MFN=57007 
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Descriptor English:   High-Temperature Requirement A Serine Peptidase 1 
Descriptor Spanish:   serina peptidasa A1 que requiere temperaturas altas 
Descriptor Portuguese:   Serina Peptidase 1 de Requerimento de Alta Temperatura A 
Synonyms English:   HTRA1, Serine Protease
High Temperature Requirement A Serine Peptidase 1
Protease HTRA1, Serine
Serine Protease HTRA1  
Tree Number:   D08.811.277.656.300.760.420
D08.811.277.656.959.350.420
Definition English:   A secreted serine protease that contains a Kazal domain-like region and a C-terminal PDZ domain. It has a broad range of targets that include EXTRACELLULAR MATRIX PROTEINS; PROTEOGLYCANS; and INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS. Mutations in the HTRA1 gene are associated with AGE-RELATED MACULAR DEGENERATION 7 and Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL). 
See Related English:   Kazal Motifs
PDZ Domains
 
History Note English:   2018 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   57007 
Unique Identifier:   D000074289 

Occurrence in VHL:
 

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