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DeCS
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Descriptor English:
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High-Temperature Requirement A Serine Peptidase 2
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Descriptor Spanish:
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serina peptidasa A2 que requiere temperaturas altas
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Descriptor Portuguese:
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Serina Peptidase 2 de Requerimento de Alta Temperatura A
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Synonyms English:
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HTRA2, Serine Protease
High Temperature Requirement A Serine Peptidase 2
HtrA Serine Peptidase 2
HtrA2 Protease
Omi Serine Protease
Omi, Serine Protease
Protease HTRA2, Serine
Protease Omi, Serine
Protease, HtrA2
Protease, Omi Serine
Serine Protease HTRA2
Serine Protease Omi
Serine Protease, Omi
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Tree Number:
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D08.811.277.656.300.760.431
D08.811.277.656.959.350.431
D12.644.360.075.429
D12.776.476.075.429
D12.776.575.656
D12.776.637.625
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Definition English:
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A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE. |
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See Related English:
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PDZ Domains
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History Note English:
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2018 (2000)
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Allowable Qualifiers English:
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Record Number:
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57008
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Unique Identifier:
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D000074923
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Occurrence in VHL:
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Similar:
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DeCS
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