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DeCS
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Descriptor English:
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Lysine Acetyltransferase 5
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Descriptor Spanish:
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lisina acetiltransferasa 5
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Descriptor Portuguese:
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Lisina Acetiltransferase 5
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Synonyms English:
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HIV 1 Tat Interactive Protein Tip60
HIV-1-Tat Interactive Protein Tip60
HTATIP
KAT5 (TIP60) Protein
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Tree Number:
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D08.811.913.050.134.415.500.062
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Definition English:
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A catalytic subunit of the NuA4 histone acetyltransferase complex that functions in transcriptional activation of genes by acetylation of nucleosomal HISTONES H4 and H2A, altering nucleosome-DNA interactions and interaction of the modified histones with other activating transcription factors. It may control gene expression changes associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest; CELL AGING; APOPTOSIS; and DNA REPAIR. It is polyubiquitinated and degraded during HIV-1 infection through its interaction with the viral TAT PROTEIN. |
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History Note English:
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2018
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Allowable Qualifiers English:
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Record Number:
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57027
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Unique Identifier:
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D000074443
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Occurrence in VHL:
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Similar:
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DeCS
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