Search on:
MFN=57034
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
c-Mer Tyrosine Kinase
Descriptor
Spanish
:
tirosina cinasa c-Mer
Descriptor
Portuguese
:
c-Mer Tirosina Quinase
Synonyms
English
:
Kinase, c-Mer Tyrosine
MERTK
Tyrosine Kinase, c-Mer
c Mer Proto Oncogene Tyrosine Kinase
c Mer Tyrosine Kinase
c-Mer Proto-Oncogene Tyrosine Kinase
Tree Number:
D08.811.913.696.620.682.725.400.003
D12.776.543.750.630.003
D12.776.624.664.700.037
Definition
English
:
A receptor
tyrosine
kinase that transduces signals from
EXTRACELLULAR MATRIX
to the
CYTOPLASM
by binding
ligands
such as
GALECTIN 3
. It regulates many physiologic processes that include
cell survival
, migration, differentiation, and
PHAGOCYTOSIS
of apoptotic cells and ROD PHOTORECEPTORS in the
RETINAL PIGMENT EPITHELIUM
.
Mutations
in the MERTK gene are associated with type 38
RETINITIS PIGMENTOSA
; it also plays a critical role as an inhibitor of
TOLL-LIKE RECEPTORS
signaling.
History Note
English
:
2018
Allowable Qualifiers
English
:
AD
administration & dosage
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PH
physiology
RE
radiation effects
TU
therapeutic use
UL
ultrastructure
Record Number:
57034
Unique Identifier:
D000076202
Occurrence in VHL
:
Similar:
DeCS