Search on: MFN=57058 
Descriptors Found: 1
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Descriptor English:   T-Lymphoma Invasion and Metastasis-inducing Protein 1 
Descriptor Spanish:   proteína 1 de invasión e inducción de metástasis del linfoma-T 
Descriptor Portuguese:   Proteína 1 Indutora de Invasão e Metástase de Linfoma de Células T 
Synonyms English:   T Lymphoma Invasion and Metastasis inducing Protein 1
TIAM 1 Protein
TIAM-1 Protein
TIAM1 Protein  
Tree Number:   D12.644.360.325.300.850
D12.776.476.325.300.850
Definition English:   A Rho guanine nucleotide exchange factor that consists of two pleckstrin homology domains flanking central Ras-binding, Dbl-homology (DH) and PDZ domains. It stimulates GTP-GDP exchange of rho-like GTPases such as RAC1 PROTEIN; CDC42 PROTEIN; and RHOA PROTEIN, and functions to link extracellular signals to remodeling of the CYTOSKELETON for CELL ADHESION and CELL MOVEMENT. 
See Related English:   PDZ Domains
Pleckstrin Homology Domains
 
History Note English:   2018 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   57058 
Unique Identifier:   D000075684 

Occurrence in VHL:
 

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