Search on: MFN=57077 
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Descriptor English:   TRPC6 Cation Channel 
Descriptor Spanish:   canal catiónico TRPC6 
Descriptor Portuguese:   Canal de Cátion TRPC6 
Synonyms English:   Cation Channel, TRPC6
Channel, TRPC6 Cation
TRPC6
Transient Receptor Potential Cation Channel Subfamily C, Member 6  
Tree Number:   D12.776.157.530.400.150.850
D12.776.157.530.400.901.500.500
D12.776.543.550.450.150.900
D12.776.543.585.400.150.850
D12.776.543.585.400.901.500.500
Definition English:   A non-selective, calcium permeant TRPC cation channel that contains four ANKYRIN REPEATS and is activated by DIACYLGLYCEROL independently of PROTEIN KINASE C. It is expressed in placenta, lung, spleen, ovary and the small intestine, as well as by PODOCYTES in the kidney glomerulus. Mutations in the TRPC6 gene are associated with FOCAL SEGMENTAL GLOMERULOSCLEROSIS type 2. 
History Note English:   2018 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   57077 
Unique Identifier:   D000074287 

Occurrence in VHL:
 

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