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MFN=57095
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DeCS
Descriptor
English
:
CCCTC-Binding Factor
Descriptor
Spanish
:
factor de unión a CCCTC
Descriptor
Portuguese
:
Fator de Ligação a CCCTC
Synonyms
English
:
CCCTC Binding Factor
CTCF Protein
CTCF, DNA-Binding Protein
DNA Binding Protein CTCF
DNA-Binding Protein CTCF
Tree Number:
D12.776.157.687.157
D12.776.260.120
D12.776.660.235.050
D12.776.660.720.157
D12.776.664.235.050
D12.776.930.780.563
Definition
English
:
A repressor protein with poly(ADP)-ribose binding activity that binds
CHROMATIN
and DNA; its structure consisting of 11
CYS2-HIS2 ZINC FINGERS
allows it to recognize many different DNA target sites. It functions as a repressor by binding to
INSULATOR ELEMENTS
and preventing interaction between promoters and nearby enhancers and silencers. It plays a critical role in EPIGENETIC PROCESSES, including
GENOMIC IMPRINTING.
History Note
English
:
2018 (1998)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
57095
Unique Identifier:
D000076246
Occurrence in VHL
:
Similar:
DeCS