Search on: MFN=57110 
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Descriptor English:   Pre-B-Cell Leukemia Transcription Factor 1 
Descriptor Spanish:   factor de transcripción 1 de la leucemia de células pre-B 
Descriptor Portuguese:   Fator de Transcrição 1 de Leucemia de Células Pré-B 
Synonyms English:   Homeobox Protein, PBX1
PBX1 Homeobox Protein
Pre B Cell Leukemia Homeobox 1 Protein
Pre B Cell Leukemia Transcription Factor 1
Pre-B-Cell Leukemia Homeobox 1 Protein  
Tree Number:   D12.776.260.400.836
D12.776.624.664.700.163
D12.776.930.712
Definition English:   A TALE-type homeodomain protein and transcription factor that binds the DNA sequence 5'-ATCAATCAA-3'. It forms a heterodimer with MEIS1 TRANSCRIPTION FACTOR and functions as a transcriptional activator of HOMEOBOX PROTEIN NKX-2.5 and ELONGIN A, and as a transcriptional repressor of CDKN2B PROTEIN, in the regulation of developmental and morphogenetic processes such as spleen and limb development. Chromosome translocations involving the PBX1 and TCF3 genes occur in cases of pre-B-cell ACUTE LYMPHOID LEUKEMIA. 
History Note English:   2018 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   57110 
Unique Identifier:   D000075062 

Occurrence in VHL:
 

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