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DeCS
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Descriptor English:
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Zinc Finger Protein Gli3
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Descriptor Spanish:
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proteína Gli3 con dedos de zinc
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Descriptor Portuguese:
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Proteína Gli3 com Dedos de Zinco
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Synonyms English:
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GLI Kruppel Family Member 3 Protein
GLI-Kruppel Family Member 3 Protein
Glioma Associated Oncogene Family Zinc Finger 3 Protein
Glioma-Associated Oncogene Family Zinc Finger 3 Protein
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Tree Number:
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D12.776.260.522.875
D12.776.260.703.900
D12.776.930.375.875
D12.776.930.780.972
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Definition English:
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A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES. |
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History Note English:
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2018
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Allowable Qualifiers English:
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Record Number:
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57117
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Unique Identifier:
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D000074290
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Occurrence in VHL:
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Similar:
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DeCS
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