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DeCS
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Descriptor English:
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Forkhead Box Protein L2
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Descriptor Spanish:
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proteína forkhead box L2
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Descriptor Portuguese:
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Proteína Forkhead Box L2
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Synonyms English:
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FOXL2 Protein
Forkhead Box L2 Protein
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Tree Number:
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D12.776.260.950.249.032
D12.776.930.977.249.032
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Definition English:
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A forkhead box transcription factor that is expressed in the developing eyelid and during very early development of the gonad, prior to sex determination. It is essential for development of the ovary and inhibits SOX9 TRANSCRIPTION FACTOR to prevent differentiation to testes. It also induces APOPTOSIS in ovarian cells. Mutations in the FOXL2 gene are associated with BLEPHAROPHIMOSIS; Ptosis, and Epicanthus inversus (BPES with ovarian failure). |
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History Note English:
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2018
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Allowable Qualifiers English:
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Record Number:
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57121
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Unique Identifier:
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D000074842
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Occurrence in VHL:
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Similar:
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DeCS
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