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DeCS

Descriptor English:

Fanconi Anemia Complementation Group N Protein

Descriptor Spanish:

proteína del grupo de complementación N de la anemia de Fanconi

Descriptor Portuguese:

Proteína do Grupo de Complementação N da Anemia de Fanconi

Synonyms English:

FANCN Protein
PALB2 Protein
Partner and Localizer of BRCA2 Protein

Tree Number:

Definition English:

A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER.

History Note English:

2018

Allowable Qualifiers English:

Record Number:

57122

Unique Identifier:

D000076164

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