Search on: MFN=57152 
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Descriptor English:   Vasopeptidase Inhibitors 
Descriptor Spanish:   inhibidores de las vasopeptidasas 
Descriptor Portuguese:   Inibidores de Vasopeptidases 
Synonyms English:   ACE NEP Inhibitors
ACE-NEP Inhibitors
NEP ACE Inhibitors
NEP-ACE Inhibitors  
Tree Number:   D27.505.519.389.745.085.500
Definition English:   A class of cardiovascular drugs indicated for hypertension and congestive heart failure that simultaneously inhibit both NEUTRAL ENDOPEPTIDASE and ANGIOTENSIN CONVERTING ENZYME. They increase the availability of NATRIURETIC PEPTIDES and BRADYKININ and inhibit production of ANGIOTENSIN II. 
History Note English:   2018 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AA analogs & derivatives BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   57152 
Unique Identifier:   D000075563 

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