Pesquisa sobre: MFN=56982 
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Descritor Inglês:   Mechanistic Target of Rapamycin Complex 1 
Descritor Espanhol:   diana mecanicista del complejo 1 de la rapamicina 
Descritor Português:   Alvo Mecanístico do Complexo 1 de Rapamicina 
Sinônimos Inglês:   TOR Complex 1
Target of Rapamycin Complex 1
mTORC1 Complex
Complex, mTORC1  
Categoria:   D05.500.337
Definição Inglês:   An evolutionarily conserved multiprotein complex that functions as a cellular energy sensor and regulator of protein synthesis for cell growth and proliferation. It consists of TOR SERINE-THREONINE KINASES; REGULATORY-ASSOCIATED PROTEIN OF MTOR (RAPTOR); MLST8 PROTEIN; and AKT1 substrate 1 protein. The activity of the complex is regulated by SIROLIMUS; INSULIN; GROWTH FACTORS; PHOSPHATIDIC ACIDS; some amino acids or amino acid derivatives, and OXIDATIVE STRESS. 
Nota Histórica Inglês:   2018 (2013) 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   56982 
Identificador Único:   D000076222 

Ocorrência na BVS:
MEDLINE     2491