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MFN=56995
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DeCS
Descritor
Inglês
:
Spastin
Descritor
Espanhol
:
espastina
Descritor
Português
:
Espastina
Sinônimos
Inglês
:
Spastic Paraplegia 4 Protein
Categoria:
D08.811.277.040.013.500.500
D08.811.277.040.025.024.500
D12.776.157.025.750.500
D12.776.220.600.450.465
D12.776.631.560.480
Definição
Inglês
:
An AAA ATPase that binds and severs
MICROTUBULES
. It specifically recognizes and cuts polyglutamylated
microtubules
with short
polyglutamate
tails to promote reorganization of cellular
microtubule
arrays and the release of
microtubules
from the
CENTROSOME
following nucleation. It is critical for the biogenesis and
maintenance
of complex
microtubule
arrays in AXONS;
SPINDLE APPARATUS
; and CILIA.
Mutations
in the
spastin
gene (SPAST) are associated with type 4 of HEREDITARY SPASTIC
PARAPLEGIA.
Relacionados
Inglês
:
AAA Domain
Nota Histórica
Inglês
:
2018
Qualificadores Permitidos
Inglês
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número do Registro:
56995
Identificador Único:
D000074181
Ocorrência na BVS
:
Similar:
DeCS