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DeCS
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Descritor Inglês:
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SAM Domain and HD Domain-Containing Protein 1
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Descritor Espanhol:
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proteína 1 que contiene dominios SAM y HD
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Descritor Português:
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Proteína 1 com Domínio SAM e Domínio HD
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Sinônimos Inglês:
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SAM Domain and HD Domain Containing Protein 1
SAMHD1 Deoxynucleoside Triphosphate Triphosphohydrolase
SAMHD1 Protein
SAMHD1 dNTPase
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Categoria:
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D08.811.277.040.725
D08.811.277.352.700.843
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Definição Inglês:
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A host restriction triphosphorylhydrolase and dNTPase that contains an N-terminal STERILE ALPHA MOTIF and central, conserved ASPARTATE and HISTIDINE (HD) domain. It acts on single-stranded RNA, yielding deoxynucleosides and triphosphate, and functions in anti-viral defense through its dNTPase activity, reducing cellular dNTP levels below what is required for retroviral reverse transcription in DENDRITIC CELLS and MYELOID CELLS. It also has RIBONUCLEASE activity which blocks early replication of retroviruses such as HIV-1. Mutations in the SAMHD1 gene are associated with type 5 Aicardi-Goutieres syndrome (AGS5) and type 2 chilblain LUPUS (CHBL2). |
Nota Histórica Inglês:
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2018
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Qualificadores Permitidos Inglês:
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Número do Registro:
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57002
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Identificador Único:
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D000076106
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Ocorrência na BVS:
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Similar:
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DeCS
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