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MFN=57012
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DeCS
Descritor
Inglês
:
F-Box-WD Repeat-Containing Protein 7
Descritor
Espanhol
:
proteína 7 que contiene repeticiones F-Box-WD
Descritor
Português
:
Proteína 7 com Repetições F-Box-WD
Sinônimos
Inglês
:
F Box WD Repeat Containing Protein 7
F Box and WD 40 Domain Containing Protein 7
F-Box and WD-40 Domain-Containing Protein 7
FBXW7 Protein
Categoria:
D08.811.464.938.750.750.750
D12.776.157.169.750
D12.776.167.242
Definição
Inglês
:
A component of SCF(FBW7)
UBIQUITIN
LIGASE that contains an F-box motif and multiple WD REPEATS. It recognizes and binds phosphorylated signals in several
proteins
involved in
CELL PROLIFERATION
and targets them to the SCF complex for
UBIQUITINATION
. Targets include
CYCLIN E
;
PROTO-ONCOGENE PROTEINS C-JUN
;
PROTO-ONCOGENE PROTEINS C-MYC
; and
JNK MITOGEN-ACTIVATED PROTEIN KINASES.
Nota Histórica
Inglês
:
2018
Qualificadores Permitidos
Inglês
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número do Registro:
57012
Identificador Único:
D000073979
Ocorrência na BVS
:
Similar:
DeCS