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DeCS
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Descritor Inglês:
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DCC Receptor
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Descritor Espanhol:
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receptor DCC
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Descritor Português:
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Receptor DCC
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Sinônimos Inglês:
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DCC Netrin 1 Receptor
DCC Tumor Suppressor Protein
DCC-Netrin-1 Receptor
Deleted in Colorectal Carcinoma Protein
Receptor, DCC
Receptor, DCC-Netrin-1
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Categoria:
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D12.644.360.075.413
D12.776.476.075.413
D12.776.543.750.003.500
D12.776.624.776.021
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Definição Inglês:
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A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2 domains and six membrane proximal (C-terminal) fibronectin type III domains. It is expressed primarily in the nerve axons and differentiated intestinal cells and is required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however, it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor. DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC gene are observed in tumor metastases and the protein is not expressed in undifferentiated COLORECTAL CARCINOMA cells. |
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Nota Histórica Inglês:
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2018
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Qualificadores Permitidos Inglês:
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Número do Registro:
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57057
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Identificador Único:
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D000075389
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Ocorrência na BVS:
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Similar:
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DeCS
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