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DeCS
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Descriptor English:
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Complement C1s
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Descriptor Spanish:
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complemento C1s
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Descriptor Portuguese:
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Complemento C1s
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Synonyms English:
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C 1 Esterase
C1 Esterase
C1s Complement
C1s, Complement
Complement 1 Esterase
Complement 1s
Complement Component 1s
Complement, C1s
Component 1s, Complement
Esterase, C 1
Esterase, C1
Esterase, Complement 1
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Tree Number:
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D08.811.277.300.290
D12.776.124.486.274.045.290
D12.776.124.486.274.050.290
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Definition English:
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A 77-kDa subcomponent of complement C1, encoded by gene C1S, is a SERINE PROTEASE existing as a proenzyme (homodimer) in the intact complement C1 complex. Upon the binding of COMPLEMENT C1Q to antibodies, the activated COMPLEMENT C1R cleaves C1s into two chains, A (heavy) and B (light, the serine protease), linked by disulfide bonds yielding the active C1s. The activated C1s, in turn, cleaves COMPLEMENT C2 and COMPLEMENT C4 to form C4b2a (CLASSICAL C3 CONVERTASE). |
Pharmacological Action:
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Immunologic Factors
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History Note English:
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2006 (1978)
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Allowable Qualifiers English:
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Record Number:
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28242
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Unique Identifier:
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D003173
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Occurrence in VHL:
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Similar:
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DeCS
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