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DeCS
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Descriptor English:
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Didanosine
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Descriptor Spanish:
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didanosina
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Descriptor Portuguese:
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Didanosina
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Synonyms English:
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2',3' Dideoxyinosine
2',3'-Dideoxyinosine
Dideoxyinosine
NSC 612049
NSC-612049
NSC612049
Videx
ddI (Antiviral)
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Tree Number:
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D03.633.100.759.590.616.130
D13.570.230.500.090
D13.570.583.616.130
D13.570.800.573.130
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Definition English:
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A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite. |
Pharmacological Action:
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Antimetabolites
Reverse Transcriptase Inhibitors
Anti-HIV Agents
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History Note English:
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92; was DIDEOXYINOSINE 1990-91
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Allowable Qualifiers English:
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Record Number:
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30328
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Unique Identifier:
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D016049
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Occurrence in VHL:
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Similar:
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DeCS
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