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PH DOMAINS
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DeCS
Descriptor
English
:
Pleckstrin Homology Domains
Descriptor
Spanish
:
dominios homólogos a pleckstrina
Descriptor
Portuguese
:
Domínios de Homologia à Plecstrina
Synonyms
English
:
Domain, PH
Domain, Pleckstrin Homology
Domains, PH
Domains, Pleckstrin Homology
Homology Domain, Pleckstrin
Homology Domains, Pleckstrin
PH Domain
PH Domains
Pleckstrin Homology Domain
Tree Number:
G02.111.570.820.709.275.750.469
Definition
English
:
Protein domains
of approximately 120
amino acids
that form two perpendicular anti-parallel beta sheets connected by a loop of variable length and a C-terminal amphipathic helix. PH domains occur in many INTRACELLULAR SIGNALING
PROTEINS
and
CYTOSKELETAL PROTEINS
where they bind
PHOSPHATIDYLINOSITOLS
within the
CELL MEMBRANE
and
INTRACELLULAR MEMBRANES
, as well as
proteins
that include the Betagamma-subunits of
HETEROTRIMERIC GTP-BINDING PROTEINS
, and
PROTEIN KINASE C
. These interactions allow the targeting of
proteins
to different cellular compartments and
SIGNAL TRANSDUCTION
PATHWAYS.
History Note
English
:
2017
Allowable Qualifiers
English
:
DE
drug effects
GE
genetics
IM
immunology
PH
physiology
RE
radiation effects
Record Number:
56742
Unique Identifier:
D000070539
Occurrence in VHL
:
Similar:
DeCS