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DeCS
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Descriptor Inglés:
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X-linked Nuclear Protein
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Descriptor Español:
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proteína nuclear ligada al cromosoma X
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Descriptor Portugués:
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Proteína Nuclear Ligada ao X
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Sinónimos Inglés:
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ATRX Protein
Homolog Protein, RAD54
Nuclear Protein, X-linked
RAD54 Homolog Protein
X linked Nuclear Protein
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Categoría:
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D08.811.399.340.375
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Definición Inglés:
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ATP-dependent DNA helicase that contains two N-terminal ZINC FINGERS and C-terminal ATP-binding and helicase domains. It functions in the regulation of gene transcription and CHROMATIN REMODELING. ATRX undergoes cell-cycle dependent phosphorylation, which causes it to translocate from the NUCLEAR MATRIX to CHROMATIN; thus, it may change its role from gene regulation during INTERPHASE to ensuring proper chromosome segregation at MITOSIS. Mutations in the ATRX gene are associated with cases of X-LINKED MENTAL RETARDATION co-morbid with ALPHA-THALASSEMIA (ATRX syndrome). |
Relacionados Inglés:
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PHD Zinc Fingers
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Nota Histórica Inglés:
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2018
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Calificadores Permitidos Inglés:
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Número del Registro:
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57010
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Identificador Único:
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D000075924
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Ocurrencia en la BVS:
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Similar:
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DeCS
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